909 Developing a 3D microfluidic model of immune-competent human skin using autologous cells
نویسندگان
چکیده
منابع مشابه
Immune Competent Human Skin and Gingiva Equivalent Models
Although animals, in particular mice, are used extensively for skin models, misleading conclusions can be made due to very clear differences between human and animal immunology as illustrated by the fact that extensive differences have been reported between human and mouse DC subsets (Shortman and Liu, 2002;van de Ven et al., 2011). Importantly, no suitable animal models exist to study oral imm...
متن کاملThe development of a 3D immunocompetent model of human skin.
As the first line of defence, skin is regularly exposed to a variety of biological, physical and chemical insults. Therefore, determining the skin sensitization potential of new chemicals is of paramount importance from the safety assessment and regulatory point of view. Given the questionable biological relevance of animal models to human as well as ethical and regulatory pressure to limit or ...
متن کاملDeveloping a predictive model of human skin colouring
A model of colour formation within human skin has been developed to aid the characterisation of pigmented skin lesions from their digitized colour images. The model is based on the Kublenka–Munk theory of scattering and absorption within inhomogeneous materials and the physics pertaining to their colour properties. By considering the skin to be a layered construction of such materials, the stra...
متن کاملSkin corrosion and irritation test of sunscreen nanoparticles using reconstructed 3D human skin model
OBJECTIVES Effects of nanoparticles including zinc oxide nanoparticles, titanium oxide nanoparticles, and their mixtures on skin corrosion and irritation were investigated by using in vitro 3D human skin models (KeraSkin ((TM)) ) and the results were compared to those of an in vivo animal test. METHODS Skin models were incubated with nanoparticles for a definite time period and cell viability...
متن کاملthe use of appropriate madm model for ranking the vendors of mci equipments using fuzzy approach
abstract nowadays, the science of decision making has been paid to more attention due to the complexity of the problems of suppliers selection. as known, one of the efficient tools in economic and human resources development is the extension of communication networks in developing countries. so, the proper selection of suppliers of tc equipments is of concern very much. in this study, a ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2017
ISSN: 0022-202X
DOI: 10.1016/j.jid.2017.02.936